Journal of Space Science and Technology

Journal of Space Science and Technology

Evaluating Optimal Ultrasound to Deform the Blood Clot in a Vessel for Astronauts Health

Document Type : Original Research Paper

Authors
1 Aerospace Research Institute, Ministry of Science, Research and Technology, Tehran, Iran
2 Department of Mathematical Sciences, Kent State University, Ohio, USA
3 Department of Electrical Engineering, Khatam University, Tehran, Iran
4 Department of Engineering, University of Perugia, Perugia, Italy
Abstract
Formation of blood clot in the astronaut veins in space may have dangerous consequences. In the absence of gravity, body fluids shift from the legs to the upper body and the head. This shift affects the flow of blood through the vessels in the head. Removing of the blood clot in the vessels in space may help astronauts’ health. Although using the medicine to remove the blood clot in the vein, it can be applied just for very small size. When the blood clot is large, using the ultrasonic waves with making small bubbles may be a useful method to remove the blood clots in the veins. The goal of the present paper is to gain an optimal intensity of ultrasound to achieve required pressure field generated by the collapsing bubble in blood to deform blood clots. The collapse pressure within the bubble has been calculated using Rayleigh–Plesset (RP) equation. Moreover, a coupling simulation of the flow and clot structure is performed using the full Navier-Stokes equations, which governs the blood domain, and linearized discrete equations for the clot medium to calculate the desired bubble collapsing pressure necessary to deform the clots, which has immense importance in medical applications. Simulation results are presented to show the effectiveness of the proposed method. Using the captured results, one can find the optimum ultrasound frequency for clot fragment. It can be useful for an astronaut to use the ultrasonic waves to remove some clots in the vein, treat and get back the health.
Keywords

Subjects


Article Title Persian

ارزیابی شدت بهینه امواج اولتراسوند برای تغییر شکل لخته خون در رگ‌ها به منظور سلامت فضانوردان

Authors Persian

رامین کمالی مقدم 1
محمود نجفی 2
معصومه آزادگان 3
نسرین صحرانورد فر 4
1 پژوهشگاه هوافضا
2 گروه علوم ریاضی، دانشگاه ایالتی کنت، اوهایو، ایالات متحده آمریکا
3 دانشکده مهندسی برق، دانشگاه خاتم، تهران، ایران
4 دانشکده مهندسی، دانشگاه پروجا، پروجا، ایتالیا
Abstract Persian

تشکیل لخته خون در رگ‌های فضانوردان در فضا می‌تواند پیامدهای خطرناکی به همراه داشته باشد. در نبود گرانش، مایعات بدن از پاها به سمت سینه و سر منتقل می‌شوند. این جابه‌جایی بر جریان خون در شریان‌ها و رگ‌های سر تأثیر می‌گذارد. خارج‌سازی لخته خون در رگ‌های فضایی می‌تواند به بهبود سلامت فضانوردان کمک کند. هرچند استفاده از دارو برای از بین بردن لخته خون در ورید فقط برای اندازه‌های بسیار کوچک کاربرد دارد. زمانی که لخته خون بزرگ است، استفاده از امواج اولتراسوند با ایجاد حباب‌های کوچک می‌تواند روشی مفید برای از بین بردن لخته‌ها در رگ‌ها باشد. هدف مقاله حاضر دستیابی به شدت بهینه امواج اولتراسوند است تا با ایجاد میدان فشار لازم ناشی از فروپاشی حباب در خون، لخته‌ها را تغییر شکل دهد. فشار فروپاشی درون حباب با استفاده از معادله Rayleigh–Plesset (RP) محاسبه شده است. علاوه بر این، یک شبیه‌سازی هم‌پیوندی جریان و ساختار لخته با استفاده از معادلات کامل ناویه-استوکس که حوزه خون را می‌سازند و معادلات گسسته خطی‌شده برای محیط لخته برای محاسبه فشار فروپاشی مطلوب حباب که برای تغییر شکل لخته‌ها ضروری است، انجام می‌شود؛ که این امر در کاربردهای پزشکی اهمیت بالایی دارد. نتایج شبیه‌سازی برای نشان دادن کارایی روش پیشنهادی ارائه می‌شود.

Keywords Persian

دینامیک حباب
کنترل امواج اولتراسوند
دینامیک سیالات محاسبه شده سه‌بعدی
تغییر شکل لخته خون
سلامت فضانوردان
[1] WebMD Medical Reference Reviewed by James Beckerman, MD, FACC on March 21, 2019.
[2] F. Bajd and I. Serša, “Mathematical modeling of blood clot fragmentation during flow-mediated thrombolysis,” Biophysical journal, vol. 104, no. 5, pp. 1181-1190, 2013.
[3] J. M. Wardlaw, V. Murray, E. Berge, and G. J. Del Zoppo, “Thrombolysis for acute ischaemic stroke,” Cochrane Database of Systematic Reviews (7), 2014, https://doi.org/10.1002/14651858.CD000213.pub3.
[4] L. R. Wechsler, “Intravenous thrombolytic therapy for acute ischemic stroke,” the New England Journal of Medicine, vol. 364, no. 22, pp. 2138–2146, 2011, https://doi.org/10.1056/NEJMct1007370.
[5] E. A. Mistry et al., “Mechanical thrombectomy outcomes with and without intravenous thrombolysis in stroke patients: A meta-analysis,” Stroke, vol. 48, no. 9, pp. 2450–2456, 2017, https://doi.org/10.1161/STROKEAHA.117.017320.
[6] S. Z. Goldhaber, L. Visani, and M. De rosa, “Acute pulmonary embolism: Clinical outcomes in the international cooperative pulmonary embolism registry (ICOPEr),” Lancet, vol. 353, no. 9162, pp. 1386–1389, 1999.
[7] S. Z. Goldhaber et al., “Alteplase versus heparin in acute pulmonary embolism: Randomised trial assessing right ventricular function and pulmonary perfusion,” Lancet, vol. 341, no. 8844, pp. 507–511, 1993, https://doi.org/10.1016/0140-6736(93)90274-K.
[8] K. Ouriel, F. J. Veith, and A. A. Sasahara, “A comparison of recombinant urokinase with vascular surgery as initial treatment for acute arterial occlusion of the legs,” the New England Journal of Medicine, vol. 338, no. 16, pp. 1105–1111, 1998, https://doi.org/10.1056/NEJM19980416338160.
[9] F. R. Young, Cavitation, London, UK: Imperial College Press, 1999.
[10] T. J. Mason, Advances in Sonochemistry, vol. 1–6, Amsterdam, The Netherlands: Elsevier, 1990–2001.
[11] K. S. Suslick, Ultrasound: Its chemical, physical, and biological effects, New York: VCH Publishers, 1988.
[12] R. k. Bhaskaracharya, S. Kentish, and M. Ashokkumar, “Selected applications of ultrasonics in food processing,” Food Engineering Reviews, vol. 1, no. 1, pp. 31–49, 2009, https://doi.org/10.1007/s12393-009-9003-7.
[13] D. L. Miller et al., “Overview of therapeutic ultrasound applications and safety considerations,” Journal of Ultrasound in Medicine, vol. 31, no. 4, pp. 623-634, 2012, https://doi.org/10.7863/jum.2012.31.4.623.
[14] U. B. Mahatme, M. Archana, S. P. Dongre, A. S. Nakhate, and A. V. Tabhane, “Applications of ultrasound in medical science: A review,” in International Symposium on Ultrasonics, Nagpur, Maharashtra, India, 2015, pp. 134-144.
[15] F. R. Young, Cavitation, London: McGraw-Hill, 1994.
[16] Sh. Niazi, S. H. Hashemabadi, and M. Mirarab Razi, “CFD simulation of acoustic cavitation in a crude oil upgrading sonoreactor and prediction of collapse temperature and pressure of a cavitation bubble,” Chemical Engineering Research and Design, vol. 92, no. 1, pp. 166-173, 2014, https://doi.org/10.1016/j.cherd.2013.07.002.
[17] S. Merouani, O. Hamdaoui, Y. Rezgui, and M. Guemini, “Theoretical estimation of the temperature and pressure within collapsing acoustical bubbles,” Ultrasonics Sonochemistry, vol. 21, no. 1, pp. 53–59, 2014, https://doi.org/10.1016/j.ultsonch.2013.05.008.
[18] S. Li, R. Han, A. M. Zhang, and Q. X. Wang, “Analysis of pressure field generated by a collapsing bubble,” Ocean Engineering, vol. 117, pp. 22-38, 2016, https://doi.org/10.1016/j.oceaneng.2016.03.016.
[19] K. Y. Kim, K. T. Byun, and H. Y. Kwak, “Temperature and pressure fields due to collapsing bubble under ultrasound,” Chemical Engineering Journal, vol. 132, no. 1-3, pp. 125-135, 2007, https://doi.org/10.1016/j.cej.2007.01.037.
[20] J. M. Brett and A. Krelle, “A study of bubble collapse pressure pulse waves from small scale underwater explosions near the water surface,” Journal of Sound and Vibration, vol. 435, pp. 91-103, 2018, https://doi.org/10.1016/j.jsv.2018.08.004.
[21] A. D. Maxwell, C. A. Cain, A. P. Duryea, L.Yuan, H. S. Gurm, and Z. Xu, “Non-invasive thrombolysis using pulsed ultrasound cavitation therapy-histotripsy,” Ultrasound in Medicine and Biology, vol. 35, no. 12, pp. 1982–1994, 2009, https://doi.org/10.1016/j.ultrasmedbio.2009.07.001.
[22] Z. Xu, T. L. Hall, J. B. Fowlkes, and C. A. Cain, “Effects of acoustic parameters on bubble cloud dynamics in ultrasound tissue erosion (histotripsy),” Journal of Acoustical Society of America, vol. 122, pp. 229–236, 2007, https://doi.org/10.1121/1.2735110.
[23] Z. Hormozi Moghaddam, M. Mokhtari Dizaji, M. Movahedin, and M. E. Ravari, “Estimation of the distribution of low-intensity ultrasound mechanical index as a parameter affecting the proliferation of spermatogonia stem cells in vitro,” Ultrasonics Sonochemistry, vol. 37, pp. 571-581, 2017, https://doi.org/10.1016/j.ultsonch.2017.02.013.
[24] M. Najafi, R. Kamali Moghadam, M. Azadegan, N. Sahranavard Fard, and M. Mohammadi, “Ultrasound bubble control for blood clot deformation in a vessel connected to a pulmonary artery,” in American Control Conference (ACC), New Orleans, LA, USA, 2021, pp. 1464-1469, https://doi.org/10.23919/ACC50511.2021.9482904.
[25] M. Mobasheri, M. Mokhtari Dizaji, T. Toliyat, and M. Mehrpour, “Destruction of recombinant tissue plasminogen activator (rtPA) -loaded echogenic liposomes under dual frequency sonication,” Journal of Kerman University of Medical Sciences, vol. 25, no. 3, pp. 243-254, 2018.
[26] M. Najafi, M. Azadegan, and M. T. Beheshti, “Stability analysis and sliding mode control of a single spherical bubble dynamics,” In American Control Conference (ACC), Boston, MA, USA, 2016, pp. 5050-5055, https://doi.org/10.1109/ACC.2016.7526154.
[27] Y. T. Shah, A. B. Pandit, and V. S. Moholkar, Cavitation Reaction Engineering, New York, N.Y.: Kluwer Academic/Plenum Publishers, 1999, P. 23.
[28] E. A. Brujan, “Collapse of cavitation bubbles in blood,” Europhysics Letters, vol. 50, no. 2, pp. 175–181, 2000, https://doi.org/10.1209/epl/i2000-00251-7.
[29] I. V. Pivkin, P. D. Richardson, and G. Karniadakis, “Blood flow velocity effects and role of activation delay time on growth and form of platelet thrombi,” National Academy of Sciences of the United States of America, vol. 103, no. 46, pp. 17164-17169, 2006, https://doi.org/10.1073/pnas.0608546103.
[30] S. L. Diamond, “Systems biology to predict blood function,” Journal of Thrombosis and Haemostasis, vol. 7, pp. 177–180, 2009, https://doi.org/10.1111/j.1538-7836.2009.03463.x.
[31] W. P. Jones and B. E. Launder, “The prediction of laminarization with a two-equation model of turbulence,” International Journal of Heat and Mass Transfer, vol. 15, no. 2, pp. 301-314, 1972, https://doi.org/10.1016/0017-9310(72)90076-2.
[32] B. E. Launder and B. I. Sharma, “Application of the energy dissipation model of turbulence to the calculation of flow near a spinning disc,” Letters in Heat and Mass Transfer, vol. 1, no. 2, pp. 131-137, 1974, https://doi.org/10.1016/0094-4548(74)90150-7.
[33]   J. E. Bardina, P. G. Huang, and T. J. Coakley, “Turbulence modeling validation, testing, and development,” NASA, Tech. Memorandum, 110446, 1997.
[34]P. C. Kohnke, Ansys Theory References, Release 5.6, 11rd ed. ANSYS Incorporated, 1999
Volume 18, Issue 4
2025
Pages 22-31

  • Receive Date 11 January 2025
  • Revise Date 02 August 2025
  • Accept Date 09 August 2025
  • First Publish Date 02 September 2025